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Seems to me it depends upon whether you are playing to win a video game, or whether you are using OOTP to simulate being a real-life manager. As others have pointed out, as far as we know pitchers don't start the day with a "this is going to be a bad start" flag raised, so having a bad inning does not predict what the future innings will look like. So if you are playing to win at a video game, then leave him in.
However if you are trying to immerse yourself as a real-life manager, then I'd think you should be ready to pull him out much earlier, say if he gives up a couple more base runners in the next inning or two. Unless bullpen is in bad shape, most managers IRL won't leave a starter out there to get pounded.
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