[mrbill]

This seems highly anecdotal. And, some pitchers do get dramatically worse after 100 pitches. Especially if their endurance isn't up for that kind of workout.

I recall a Pirates game this season where Oliver Perez took a shutout into the 9th, gave up a few baserunners and a run or two, and then the bullpen came in (rested, mind you), and proceeded to finish blowing the 4 run lead, as the Pirates eventually lost in extra innings.

I also seem to recall from watching my 'favorite' 2003 playoff game, that Pedro's OAVG before the 100th pitch was like .220, and after was over .300, over a significant period of time.