I've had experiences like this in the past.
Once, we even paid for someone to bring in their system to SI Towers and we installed some debug tools.
Using that experience, everytime it came down to something on the users machine. Once it was a new HD, another it was that they'd just installed some new memory chips.
Many other games or applications will run fine on the machine but games like OOTP push the system to the limit and suck every last bit of memory and resource (especially pre patch2).
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