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I strongly suggest to disable the virus scanner software for the complete OOTP /data directory (in My Documents/SI.../OOTP.../)
This will also increase the speed of the game.
ChuckkieB, please make a backup of the complete folder My Documents/Sports Interactive/OOTP BVaseball 2007/ (assuming that's your user data folder). Then uninstall the game and install it again. Does it work now? If it does, copy your files back into the OOTP data path, but step by step. Copy for example a saved game league folder and try to open it.
Please let us know how it worked.
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