I'm thinking that this is an unfortunate side effect of your league files continually growing in size. At some point, it becomes fairly taxing for your computer. 25 GB for one saved game folder is unusually large.
You can try cutting back on some of your settings to see if that helps your overall performance. Get rid of a lot of your old box scores and game logs. Get rid of some of your old news. Cut back on some of your stat detail, particularly for your minor leagues. I'm not sure just how extensive your extensive minor league system is, but maybe cut that back some as well.
Is there anything further that I can help you with?
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