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My league ran testing of the number of *new* injuries each month in each OOTP injury setting compared to real life in the 2010 season, and the "Low" setting was the closest to real life. The balance of pitcher to hitter injuries is going to be unrealistic in any setting and you just have to live with it.
The "talent change randomness" value is probably more significant than the injury setting. This defaults to 100, but you should probably have it around 50 (maybe even closer to 25 if you're using real life players and want them to resemble their counterparts). Most players in real life do not have their talent wiped out if they have an injury that sidelines them for just a few weeks; if you leave the Talent Change Randomness at 100, that will happen all the time.
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