I've used them in the low minors with no issues but no stunning positive results. I just want to develop a sixth pitcher as a starter on those teams with larger rosters.
I have an 18-team fictional league on which I use a 6-man rotation with the major league team because I have a dual player who DH's and plays center when he doesn't pitch. The 6-man rotation builds in an extra day of rest for him, which allows me to put him in the lineup four times every six games -- one at pitcher and three as DH/CF. I've had a lot of success with that.
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