I used to be anti-DH, but I've become very pro-DH over the last several years. It's been a reluctant conversion.
In OOTP, my fictional league uses the DH exclusively, with 7-man bullpens and 26-man active rosters. I like the fact that the DH gives me some additional flexibility when constructing my starting lineup. I don't have to be as concerned about having multiple players at one position, so there are more players that I can potentially acquire when I'm looking to upgrade my lineup. Finding short-term injury replacements is also easier.
I've often put "Wrecked" players in the DH spot to reduce the chance of injury, even if they were decent defensive players. Some of my players wouldn't have had such great careers without the DH.
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