I use 65/20/10/5 for every league, even historical. I think the heavy emphasis on ratings helps the AI to make better decisions. I use 100% scouting on historical, and normal for everything else.
Normal injuries for most leagues, but I use low for historical leagues with reserve rosters to compensate for the lack of available players.
Trade on hard/neutral. Trading is much better this year, but I still have to use self-control to avoid scamming the AI. Very Hard and/or Favor Prospects makes the ordinary reasonable trade impossible but does nothing to stop the exploits, so I don't use them.
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