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Record: 38-25, 2nd, 0.5 GB Quad City
Jose Segura hit a two-run walk-off homer in the bottom of the 10th inning off Quad City reliever Nick Wood, to give St. Louis a 6-4 win at Busch Stadium (1997).
Nick Shaw drew a one-out walk from Wood, who came on to start the inning.
Shaw threw a strike on his first pitch to Segura, his second also was in the zone and rocketed out 492 feet over the wall in right-center.
It was Segura's 22nd homer of the season.
A three-run top of the fifth, highlighted by a two-run homer from Nick Gonzalez, against River Walkers starter Zack Hunsicker stacked the Thunder to a 4-0 lead.
St. Louis started its comeback in the seventh with a pair of runs.
Jared Thomas drew a lead-off walk from reliever Cole Duensing.
Shaw followed with a double to put runners at second and third.
Segura drove in Thomas with a ground out.
A two-out single from Jean Carmona plated Shaw.
The Walkers climbed to within 4-3 in the eighth, thanks to back-to-back doubles to open the inning from Daniel Becerra and Jose Ramirez off former St. Louis reliever Travis Krogman.
Ramirez drove in the tying run with a one-out sacrifice fly off Craig Fritzler in the botton of the ninth.
It scored Carmona, who had hit the second of consecutive singles with Matt Fulton off reliever Craig Fritzler to open the inning.
A walk to Jovan GIll loaded the bases,
Becerra hit into a fielder's choice, which saw Fulton be forced out at plate.
Ramirez followed with his deep fly ball to left on a 1-2 count.
Hunsicker allowed four runs on seven hits in five innings.
After that five relievers -- Josh Grisson (1.1 IP), Yeison Santos (0.2), Cory Tiller (1.2), Josh Forgy (0.1) and Ernesto Barbosa -- combined to shutout the Thunder over the next seven innings.
Barbosa (1-0) earned his first win of the season.