This can happen if a save is corrupt.
You should hopefully be able to restore the game from the autosave function.
To restore from the automatic backup, do the following:
1) Open the game and on the start screen, click on Settings
2) Now click on the tab "Troubleshooting".
3) Click "Open folder containing saved games".
4) Now open up the league folder you're wanting to restore.
5) Then select all of the .dat files in the folder and back them up (just in case) by copying them to a temporary folder or creating a zipped file with them
6) Open the folder called "auto-save".
7) In there, select all of the ".dat" files and copy them to the league folder (the parent of the current folder) overwriting all of the ".dat" files in the league folder.
8) Now start the game and load your league
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