I always say try new things, if they work, great. If not, try something else.
My league is MLB expanded to 36 teams, all fictional players. 85 for stats.
I do things like set all teams to have a decent Market size, a strong fan base. I set all owners to 7 or higher for spending. I set all owners to 4 or 5 for win now. Every team tries to win every year, every team tries to sign good FA's. Every team turns a profit.
I do lots of things that may be unrealistic, while maintaining a good level of realism.
I set FA to 5 yrs, arby to 2 yrs. Let players get paid while they're young.
For OOTP 23 I'm going to try something a bit different. I plan to take opening day MLB, abolish the 2 leagues and have just 1 league with 6 divisions of 5 teams. Since there's interleague play and universal DH, they pretty much took away any differences between the 2 leagues, so why do we need 2 now?
This will just be a short run league for a fun adventure, maybe 50 seasons. I figure with that setup, depending on how the play-offs shake out, you could actually wind up with a Dodgers/Giants or Cubs/Cardinals, or Yankees/Red Sox World Series.
Highly unlikely, but possible.
It would be neat to see though.
Anyway, I guess my point is, if you get an idea in your head, try it out. To me OOTP is a bit like a digital camera in that sense, don't like how it turned out - hit the delete button and try again