I am currently playing a random league using 1984 as a base for output.
What I would suggest and what I did was backup up my league, then restore to test league. Set average fatigue and fast sim a season and looked at usage for the year.
Then restored to a another test league and set to high fatigue and fast sim a season then looked at usage.
Then restore to a third test league, set to very high fatigue. Fast sim the season and look at usage.
Compare all 3 and go with the one that looks best to you.
Like David said, injury settings might play a role in what you decide.
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