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You can always tune the injury setting to reduce the overall frequency, but, as others have suggested, the key is to manage your pitchers carefully. In a modern-era game, be wary that there could be cumulative effects and injury risks of having starters consistently throw 100+ pitches or relievers throw 30+ pitches too many times.
However, another strategy you can use to minimize risk is to use the September roster expansion and callups to bring up a couple of solid minor league pitchers to help take on some of the burden, especially in your bullpen. I'll use two or three pitchers like that and bring them into blowout games or use them as specialists when the matchups and situation make sense. That helps keep some of the other arms rested and fresh.
Another thing to keep in mind is the possibility that not using your pitchers for a long stretch might create injury risks. I can't say for sure that this is a feature by design in OOTP, but I've seen a number of cases where a pitcher hasn't pitched in a while, and suddenly he picks up an injury in his very next outing, especially if he goes long. If any of your injuries have occurred in similar circumstances, you might want to avoid longer stretches where someone doesn't get used.
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