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Yes, they're called the injury frequency settings (there are two).
You'll think you're doing fine and then you get an injury to a good starter or a reliever, doesn't matter, and so you need to play someone not as good not only at their spot, but also at the spot the replacement was at and all the way down the rotation or bullpen. And then you get another and another and soon enough your staff is a mix of a few pitchers you were counting on, a bunch of guys you were hoping you wouldn't have to count on too much, AAA pitchers you really hoped you wouldn't have to count on at all, and even some guys who weren't at all on your radar whom you had to acquire.
And an injury to a rotation or bullpen guy doesn't just impact that part of your staff, but the other part too. For example, if you lose a good starter, you'll probably have to play the replacement starter, and all the starters behind him, less innings than you get from the injured guy, which means you'll have to use your bullpen more. And if you lose 2 or 3 good bullpen guys you'll probably try extending your starters more which will in turn increase their risk of injury and on and on.
Can you tell I've been experiencing a vicious onslaught of injuries to my staff lately? :P Last year we had the best record in the league by 8 games and this year we're very much at risk of falling to 3rd in the division and not making the playoffs. It's okay, I like the challenge and I have both settings set to high/realistic.
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