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Auto Calc is off by default for fictional leagues, so no, I would not say that is the recommendation.
It might make sense to run it the very first year if you change the League Totals, but it shouldn't be necessary every single year.
If you do want to run it, make sure it is done on Opening Day after teams have set their rosters (so that the process is not using spring training lineups to adjust the modifiers).
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